Belgian Society of Internal Medicine

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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

18 Jul 2020 15:17 | Anonymous member (Administrator)

posted by F. Vandergheynst on FB

https://pubmed.ncbi.nlm.nih.gov/32661059/

Another very intersting finding showing the duality of dysregulated host response in Covid 19 : insufficient (regarding type I IFN) in some patients during the viral/initial phase and hyperinflammatory in some patients leading to parenchymatous and vascular lung damage. A link could be found with the results of RECOVERY published yesterday with benefit of dexamethasone during the hyperinflammatory phase and potential harm of dexamethasone in non-oxygenodependent patients, in which the drug can further impair type I IFN response.


PRESIDENT


F. Vandergheynst, MD
Erasme Hospital
Brussels
Belgium

SECRETARYS. Allard, MD
General Internal Medicine
UZ Brussels
Belgium

TREASURER


G. Decaux, MD
Erasme Hospital
Brussels
Belgium

VICE PRESIDENT


P. Lacor, MD
General Internal Medicine
UZ Brussels
Belgium
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